Diastolic blood pressure also decreased in the spray group, but not in the solution group. Heart rate increased significantly in both groups 2 min after drug administration. Although no significant differences were found between two nitroglycerin forms in any of these hemodynamic and respiratory parameters, nitroglycerin spray may have clinical advantages because of reliability in its effect, ready availability, ease of application and high stability. Your doctor may increase your dose as needed.
Children—Use and dose must be determined by your doctor. Call or other emergency services immediately if you think you are having a heart attack. If you typically use nitroglycerin to relieve angina and if one dose of nitroglycerin has not relieved your symptoms within 5 minutes, call Call if you have any of these symptoms along with chest pain : A sudden feeling of pressure, squeezing, tightness, or crushing under your breastbone.
Chest pain that spreads to your jaw, left arm, or back. Sudden, sharp chest pain with shortness of breath, especially after a long period of inactivity.
First Aiders should focus on helping the person take ASA over nitroglycerin , as long as there is no contraindication. The effects of nitrates taken under the tongue, as sublingual nitroglycerin, only last about 5 to 10 minutes or so. Longer-lasting nitroglycerin and other nitrate compounds also can be taken to prevent angina — chest pain. Chest pain or pressure can occur when the heart is not getting enough blood.
A topical gel for the treatment of erectile dysfunction is delivering explosive results through a key ingredient— nitroglycerin , the same substance found in dynamite. If you have frequent angina, your doctor may recommend taking an additional dose of nitroglycerin ; some doctors recommend a total of 2 or 3 doses 1 every 5 minutes before calling Network with colleagues and access the latest research in your field.
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Diversity in Chemistry Awards Find awards and scholarships advancing diversity in the chemical sciences. Funding to support the advancement of the chemical sciences through research projects. ACS-Hach Programs Learn about financial support for future and current high school chemistry teachers. Nitroglycerin, formally 1,2,3-propanetriol trinitrate, is a venerable explosive and, in small doses, a life-saving drug. After numerous accidents, the manufacture and distribution of the pure liquid was soon banned in many jurisdictions.
Recognizing the potential usefulness of nitroglycerin, Swedish chemist and entrepreneur Alfred Nobel sought to make a practical explosive formulation that could be handled reasonably safely.
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